Journal of Movement Disorders

Original Articles

Clinical Characteristics of Involuntary Movement in Hospitalized Patients: Kyum-Yil Kwon, Hye Mi Lee, Seon-Min Lee, Seong-Beom Koh; J Mov Disord. 2019;12(1):31-36. Published online December 20, 2018; DOI: https://doi.org/10.14802/jmd.18040

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Objective
Neurological symptoms in hospitalized patients are not rare, and neurological consultation for movement disorders is especially important in evaluating or managing those with various movement disorders. Therefore, we investigated a clinical pattern of in-hospital consultations for various movement disorders in a tertiary care university hospital.
Methods
Over two years, a total of 202 patients (70.7 ± 11.8 years of age) presenting with movement disorders referred to movement disorder specialists were investigated.
Results
The main symptoms referred by nonneurologists were tremor (56.9%), parkinsonism (16.8%), and gait disturbance (8.9%). The most frequent diagnostic category was toxic/metabolic-caused movement disorder (T/MCMD) (35%) with regard to medications, followed by Parkinson’s disease (PD) (16%). Regarding the mode of onset, T/MCMD was the leading cause for acute (68%) and subacute onset (46%), while PD was the leading disorder (31%) for chronic onset.
Conclusion
The current study showed a characteristic pattern of inpatients presenting with movement disorders. Furthermore, our findings highlighted the clinical significance of drug use or metabolic problems for treating this patient population.

Citations

Citations to this article as recorded by

Pattern and frequency of involuntary movements: hospital-based study
H. N. El Tallawy, A. S. Shalash, M. A. Abdelhamed, R. E. Elsabrout
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2023;[Epub] CrossRef
Clinical Spectrum of Movement Disorders in Neurology Inpatients in a Tertiary Care Centre
Shabeer Ahmad Paul, Gouranga Prasad Mondal, Ramesh Bhattacharyya, Kartik Chandra Ghosh, Sarbajit Das, Suman Das, Hema Krishna, Chandrakanta Patra
Journal of Neurosciences in Rural Practice.2021; 12: 581. CrossRef

Quantitative Gait Analysis in Patients with Huntington’s Disease: Seon Jong Pyo, Hanjun Kim, Il Soo Kim, Young-Min Park, Mi-Jung Kim, Hye Mi Lee, Seong-Beom Koh; J Mov Disord. 2017;10(3):140-144. Published online August 31, 2017; DOI: https://doi.org/10.14802/jmd.17041

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Abstract PDF

Objective
Gait disturbance is the main factor contributing to a negative impact on quality of life in patients with Huntington’s disease (HD). Understanding gait features in patients with HD is essential for planning a successful gait strategy. The aim of this study was to investigate temporospatial gait parameters in patients with HD compared with healthy controls.
Methods
We investigated 7 patients with HD. Diagnosis was confirmed by genetic analysis, and patients were evaluated with the Unified Huntington’s Disease Rating Scale (UHDRS). Gait features were assessed with a gait analyzer. We compared the results of patients with HD to those of 7 age- and sex-matched normal controls.
Results
Step length and stride length were decreased and base of support was increased in the HD group compared to the control group. In addition, coefficients of variability for step and stride length were increased in the HD group. The HD group showed slower walking velocity, an increased stance/swing phase in the gait cycle and a decreased proportion of single support time compared to the control group. Cadence did not differ significantly between groups. Among the UHDRS subscores, total motor score and total behavior score were positively correlated with step length, and total behavior score was positively correlated with walking velocity in patients with HD.
Conclusion
Increased variability in step and stride length, slower walking velocity, increased stance phase, and decreased swing phase and single support time with preserved cadence suggest that HD gait patterns are slow, ataxic and ineffective. This study suggests that quantitative gait analysis is needed to assess gait problems in HD.

Citations

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The semicircular canal function is preserved with little impact on falls in patients with mild Parkinson's disease
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Parkinsonism & Related Disorders.2024; 118: 105933. CrossRef
Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease
Veronika Ratz-Wirsching, Johanna Habermeyer, Sandra Moceri, Julia Harrer, Christoph Schmitz, Stephan von Hörsten
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Wearable sensors and features for diagnosis of neurodegenerative diseases: A systematic review
Huan Zhao, Junyi Cao, Junxiao Xie, Wei-Hsin Liao, Yaguo Lei, Hongmei Cao, Qiumin Qu, Chris Bowen
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Spatiotemporal Gait Parameters in Adults With Premanifest and Manifest Huntington’s Disease: A Systematic Review
Sasha Browning, Stephanie Holland, Ian Wellwood, Belinda Bilney
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Walking pattern analysis using GAIT cycles and silhouettes for clinical applications
S.M.H. Sithi Shameem Fathima, K.A. Jyotsna, Thiruveedula Srinivasulu, Kande Archana, M. Tulasi rama, S. Ravichand
Measurement: Sensors.2023; 30: 100893. CrossRef
Human Gait Analysis in Neurodegenerative Diseases: A Review
Grazia Cicirelli, Donato Impedovo, Vincenzo Dentamaro, Roberto Marani, Giuseppe Pirlo, Tiziana R. D'Orazio
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Alexandra-Maria Tăuţan, Bogdan Ionescu, Emiliano Santarnecchi
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Febryan Setiawan, Che-Wei Lin
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Nicollette L. Purcell, Jennifer G. Goldman, Bichun Ouyang, Yuanqing Liu, Bryan Bernard, Joan A. O’Keefe, Pedro Gonzalez-Alegre
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Gait variability as digital biomarker of disease severity in Huntington’s disease
Heiko Gaßner, Dennis Jensen, F. Marxreiter, Anja Kletsch, Stefan Bohlen, Robin Schubert, Lisa M. Muratori, Bjoern Eskofier, Jochen Klucken, Jürgen Winkler, Ralf Reilmann, Zacharias Kohl
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P. Stepanova, V. Srinivasan, D. Lindholm, M. H. Voutilainen
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Taneli Heikkinen, Timo Bragge, Niina Bhattarai, Teija Parkkari, Jukka Puoliväli, Outi Kontkanen, Patrick Sweeney, Larry C. Park, Ignacio Munoz-Sanjuan, Yuqing Li
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Kartikay Gupta, Aayushi Khajuria, Niladri Chatterjee, Pradeep Joshi, Deepak Joshi
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Gait Biomarkers Classification by Combining Assembled Algorithms and Deep Learning: Results of a Local Study
Eddy Sánchez-DelaCruz, Roberto Weber, R. R. Biswal, Jose Mejía, Gandhi Hernández-Chan, Heberto Gómez-Pozos
Computational and Mathematical Methods in Medicine.2019; 2019: 1. CrossRef

Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson’s Disease: Kyum-Yil Kwon, Seon Jong Pyo, Hye Mi Lee, Woo-Keun Seo, Seong-Beom Koh; J Mov Disord. 2016;9(3):144-151. Published online September 21, 2016; DOI: https://doi.org/10.14802/jmd.16012

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Abstract PDF Supplementary Material

Objective
We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson’s disease (PD).
Methods
We selected drug-naïve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score ≤ -2.
Results
Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP.
Conclusion
This exploratory study showed that baseline cognition in drug-naïve PD patients might be related to the visit-to-visit variability of DBP and/or HR.

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Review Article

Many Faces of Parkinson’s Disease: Non-Motor Symptoms of Parkinson’s Disease: Hye Mi Lee, Seong-Beom Koh; J Mov Disord. 2015;8(2):92-97. Published online May 31, 2015; DOI: https://doi.org/10.14802/jmd.15003

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Abstract PDF

Parkinson’s disease (PD) is a multi-systemic disorder that is characterized by a combination of motor and non-motor symptoms (NMS). The dopaminergic neurodegeneration of PD is involved in the genesis of NMS, but other conditions and side effects of levodopa are also associated with NMS. NMS can develop at all stage of PD and rapid eyeball movement sleep behavior disorder (RBD), constipation, depression, and olfactory dysfunction are considered prodromal signs of PD. Many NMS related with motor deficits and cognitive dysfunction. Some NMS including olfactory dysfunction, RBD and abnormal stereopsis are associated with presence of other NMS of PD. In addition, several NMS can be helpful to differentiate between idiopathic PD and other parkinsonian disorders. Early recognition and management of NMS in PD patients is important for preserving quality of life.

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The Dysfunctional Autonomic Function and “Dysfunctional” Fatigue in Drug Naïve Parkinson’s Disease
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Systems Biology Approaches to Understand the Host–Microbiome Interactions in Neurodegenerative Diseases
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Frontiers in Neuroscience.2020;[Epub] CrossRef
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Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models
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Psychogeriatrics.2020; 20(6): 880. CrossRef
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Neurological Sciences.2019; 40(2): 311. CrossRef
Cognitive Problems in Parkinson Disease: Perspectives and Priorities of Patients and Care Partners
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Cognitive and Behavioral Neurology.2019; 32(1): 16. CrossRef
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The Journal of Nutritional Biochemistry.2019; 69: 73. CrossRef
Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease
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Journal of Movement Disorders.2019; 12(2): 84. CrossRef
Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases
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Selegiline Recovers Synaptic Plasticity in the Medial Prefrontal Cortex and Improves Corresponding Depression-Like Behavior in a Mouse Model of Parkinson’s Disease
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Frontiers in Behavioral Neuroscience.2019;[Epub] CrossRef
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The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease
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Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease
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Behavioural Neurology.2019; 2019: 1. CrossRef
The effectiveness of istradefylline for the treatment of gait deficits and sleepiness in patients with Parkinson’s disease
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Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease
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Ghrelin and Neurodegenerative Disorders—a Review
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Molecular Neurobiology.2017; 54(2): 1144. CrossRef
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First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers
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Movement Disorders.2017; 32(2): 211. CrossRef
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European Journal of Neurology.2017; 24(2): 349. CrossRef
α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects
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Neurological Sciences.2017; 38(1): 171. CrossRef
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Expert Opinion on Drug Metabolism & Toxicology.2017; 13(2): 233. CrossRef
Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic
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Retinal biomarkers provide “insight” into cortical pharmacology and disease
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Pharmacology & Therapeutics.2017; 175: 151. CrossRef
Promising Effects of Neurorestorative Diets on Motor, Cognitive, and Gastrointestinal Dysfunction after Symptom Development in a Mouse Model of Parkinson's Disease
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Frontiers in Aging Neuroscience.2017;[Epub] CrossRef
DaT-SPECT assessment depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers
Moran Artzi, Einat Even-Sapir, Hedva Lerman Shacham, Avner Thaler, Avi Orr Urterger, Susan Bressman, Karen Marder, Talma Hendler, Nir Giladi, Dafna Ben Bashat, Anat Mirelman, Elisa Greggio
PLOS ONE.2017; 12(4): e0175424. CrossRef
The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies
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European Journal of Pharmacology.2017; 817: 86. CrossRef
Who Can Diagnose Parkinson's Disease First? Role of Pre-motor Symptoms
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Archives of Medical Research.2017; 48(3): 221. CrossRef
Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson’s Disease
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Current Behavioral Neuroscience Reports.2017; 4(4): 361. CrossRef
The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease
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Movement Disorders.2016; 31(1): 23. CrossRef
Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
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Journal of the Neurological Sciences.2016; 362: 59. CrossRef
Relearning of Writing Skills in Parkinson's Disease After Intensive Amplitude Training
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Movement Disorders.2016; 31(8): 1209. CrossRef
Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
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Journal of Movement Disorders.2016; 9(2): 97. CrossRef
The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group
Do-Young Kwon, Seong-Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han-Joon Kim, Hae-Won Shin, Jinyoung Youn, Kun Woo Park, Sun-Ah Choi, Sang Jin Kim, Seong-Min Choi, Ji-Yun Park, Beom S. Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong-Ho Park, Tae-Beom
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Bent out of shape: α‐Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease
Esteban Luna, Kelvin C. Luk
FEBS Letters.2015; 589(24PartA): 3749. CrossRef
Differentiated Cells Derived from Fetal Neural Stem Cells Improve Motor Deficits in a Rat Model of Parkinson's Disease
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